Factors Associated with Lesion Recurrence Following Cervical Conization.

Area of Science:

• Gynecology
• Oncology
• Infectious Diseases

Background:

• Cervical conization is a procedure to treat cervical lesions.
• Postoperative follow-up is crucial to monitor for lesion recurrence.
• Identifying reliable diagnostic tools for recurrence is essential.

Purpose of the Study:

• To investigate factors influencing cervical lesion recurrence post-conization.
• To evaluate the clinical value of human papillomavirus (HPV) testing and ThinPrep cytology test (TCT) in postoperative follow-up.
• To assess the effectiveness of these tests in diagnosing recurrence.

Main Methods:

• A study included 289 patients undergoing cervical conization.
• Patients were followed for 3 years with TCT, HPV testing, and colposcopy every 6 months.
• Data from recurrence and non-recurrence groups were analyzed to identify influencing factors and assess test performance.

Main Results:

• Factors like age, chronic diseases, parity, and transformation zone type influenced recurrence.
• HPV testing and TCT detected more abnormalities in the recurrence group post-conization.
• HPV testing alone showed high accuracy (AUC 0.861) in predicting recurrence, outperforming TCT (AUC 0.712).

Conclusions:

• Patient age, contraceptive practices, comorbidities, parity, and transformation zone type are key factors in recurrence.
• HPV testing is a sensitive and accurate predictor of cervical lesion recurrence after conization.
• HPV testing offers a significant advantage over TCT for postoperative follow-up, reducing missed diagnoses.