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Updated: Jul 23, 2025

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool

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Published on: June 30, 2014

Comorbid Conditions and Physical Function in Adults With Multiple Sclerosis.

Brenda Jeng¹, Trinh L T Huynh², Robert W Motl¹

¹Department of Physical Therapy, University of Alabama at Birmingham, Birmingham, AL; Department of Kinesiology and Nutrition, University of Illinois Chicago, Chicago, IL.

Archives of Physical Medicine and Rehabilitation

|July 13, 2023

Summary

More comorbid conditions, particularly hypertension and osteoarthritis, are linked to worse physical function in multiple sclerosis (MS) patients. Interventions targeting these conditions may improve mobility.

Keywords:

Comorbidity Exercise Hypertension Multiple sclerosis Occupational therapy Osteoarthritis Rehabilitation

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Measurements of Motor Function and Other Clinical Outcome Parameters in Ambulant Children with Duchenne Muscular Dystrophy

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Published on: January 12, 2019

Area of Science:

Neurology
Rehabilitation Medicine
Public Health

Background:

Multiple sclerosis (MS) is a chronic neurological disease affecting physical function.
Comorbid conditions are common in MS and may impact disease progression and patient outcomes.
Understanding the relationship between comorbidities and physical function is crucial for effective management.

Purpose of the Study:

To investigate the association between the total number of comorbid conditions and physical function in individuals with MS.
To identify specific common comorbidities in MS and their impact on physical function outcomes.
To explore potential targets for interventions aimed at improving physical function in MS.

Main Methods:

A cross-sectional, comparative study was conducted in a university-based laboratory setting.
Two hundred seven participants with MS (N=207) provided demographic, clinical, and comorbidity data.
Physical function was assessed using the 6-minute walk (6MW), timed 25-foot walk (T25FW), timed Up and Go (TUG), and short physical performance battery (SPPB).

Main Results:

A higher number of comorbid conditions was significantly associated with poorer scores across all physical function measures (6MW, T25FW, TUG, SPPB; P≤.001).
Individuals with MS and hypertension demonstrated worse performance on all physical function tests compared to those without hypertension.
Participants with osteoarthritis also showed diminished physical function in the 6MW, T25FW, and SPPB compared to those without osteoarthritis.

Conclusions:

Increased comorbidity burden is correlated with reduced physical function in persons with MS.
Hypertension and osteoarthritis appear to be significant contributors to physical function deficits in this population.
Behavioral interventions focusing on physical activity and diet, targeting comorbid conditions, hold promise for enhancing physical function in MS patients.