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Updated: Jul 23, 2025

Whole Mount Dissection and Immunofluorescence of the Adult Mouse Cochlea
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The Age-Related Growth of Mastoid Air Cells in Infancy: A Retrospective Cross-Sectional Study

Chenyu Chen, Xiying Huang1, Zhen Chen

  • 1Fujian Medical University, Fuzhou, China.

Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [And] European Academy of Otology and Neurotology
|July 13, 2023
PubMed

Insights

Mastoid pneumatization volume in infants aged 5 to 12 months does not significantly change with age. This study found no significant differences in mastoid air cell volume based on age, sex, or ear laterality.

Area of Science:

  • Pediatric Otolaryngology
  • Radiology
  • Human Anatomy

Background:

  • Mastoid pneumatization is crucial for middle ear development and function.
  • Understanding normal mastoid air cell volume growth in early infancy is important for identifying potential otologic disease risk factors.

Purpose of the Study:

  • To investigate the normal growth and development of mastoid pneumatization volume in infants aged 5 to 12 months.
  • To establish normative data for pediatric otosurgeons.

Main Methods:

  • Retrospective chart review of 94 infants (188 ears) aged 5 to 12 months without a history of middle ear disease.
  • Three-dimensional volume reconstruction from high-resolution computed tomography (HRCT) images.
  • Statistical analysis including one-way ANOVA and linear regression.

Main Results:

  • Mastoid pneumatization volume was found to be independent of age in the 5 to 12-month age group (p > 0.05).
  • No significant volume differences were observed between age groups, sexes, or between right and left ears.

Conclusions:

  • Mastoid air cell volume does not significantly change between 5 and 12 months of age.
  • This study provides the first 3D volume quantification of mastoid pneumatization in a large sample of early infancy.
  • Further research is needed to understand air cell volume across different age groups and populations.
Abstract

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