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Assessment of Vascular Function in Patients With Chronic Kidney Disease
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Diastolic dysfunction is an independent predictor for cardiovascular events after an acute kidney injury

Alicia Cabrera Cárdenas1, Laura Salanova Villanueva1, Ana Sánchez Horrillo1

  • 1Servicio de Nefrología, Hospital Universitario de La Princesa, Madrid, Spain.

Nefrologia
|July 13, 2023
PubMed

Insights

Diastolic dysfunction independently predicts long-term cardiovascular events following acute kidney injury (AKI). This study highlights cardiac structure

Area of Science:

  • Cardiology
  • Nephrology
  • Cardiovascular Medicine

Background:

  • Acute kidney injury (AKI) is associated with significant short- and long-term complications.
  • Cardiac function and structure may influence cardiovascular prognosis post-AKI.

Purpose of the Study:

  • To analyze the impact of cardiac function and structure on cardiovascular prognosis after in-hospital AKI.

Main Methods:

  • Observational retrospective cohort study.
  • Inclusion of in-hospital AKI episodes from 2013-2014.
  • Collection of baseline echocardiography and comorbidity data.
  • Follow-up for cardiovascular events (CVE) over 49 ± 28 months.

Main Results:

  • 1255 patients included; 39% developed CVE during follow-up.
  • Prevalent baseline cardiac abnormalities included left ventricular hypertrophy, pulmonary hypertension, and diastolic/systolic dysfunction.
  • Age, diabetes, and diastolic dysfunction were identified as independent predictors of CVE.

Conclusions:

  • Diastolic dysfunction is an independent predictor for long-term cardiovascular events after in-hospital AKI.
  • Cardiac structural and functional parameters are associated with cardiovascular outcomes post-AKI.
Abstract

Keywords:
Acute kidney injuryCardiovascular eventsDiastolic dysfunctionDisfunción diastólicaEchocardiographyEcocardiografíaEventos cardiovascularesFracaso renal agudo

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