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Updated: Jul 23, 2025

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Crosstalk between regulatory elements in disordered TRPV4 N-terminus modulates lipid-dependent channel activity

Benedikt Goretzki1,2, Christoph Wiedemann1, Brett A McCray3

  • 1Friedrich Schiller University Jena, Faculty of Chemistry and Earth Sciences, Institute of Organic Chemistry and Macromolecular Chemistry, Jena, Germany.

Nature Communications
|July 13, 2023
PubMed
Summary

Intrinsically disordered regions (IDRs) regulate TRPV4 channel activity through lipid interactions. This study reveals how IDR dynamics control TRPV4 function and highlights their importance in TRP channel regulation.

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