Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

5.2K
Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
5.2K
Carbon-13 (¹³C) NMR: Overview01:10

Carbon-13 (¹³C) NMR: Overview

5.8K
Carbon-13 is a naturally occurring NMR-active isotope of carbon with a low natural abundance of 1.1%. In contrast, carbon-12 is the most abundant isotope of carbon with zero nuclear spin. Therefore, it is NMR inactive. The gyromagnetic ratio of carbon-13 is smaller than that of protons. As a result, carbon-13 resonance is about 6000 times weaker than proton resonance. For a given magnetic field strength, the resonance frequency of carbon-13 is about one-fourth of the resonance frequency for...
5.8K
Imaging Studies IV: Magnetic Resonance Imaging01:27

Imaging Studies IV: Magnetic Resonance Imaging

29
Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...
29
Radiological Investigation II: MRI and Ventilation Perfusion Scan01:30

Radiological Investigation II: MRI and Ventilation Perfusion Scan

154
Description
Magnetic Resonance Imaging (MRI) and Ventilation Perfusion Scans are two radiological investigations that offer detailed diagnostic images of the body, particularly lung structures.
MRI
MRI uses magnetic fields and radiofrequency signals to distinguish between normal and abnormal tissues. This technology provides a more detailed diagnostic image than CT scans, enabling it to characterize pulmonary nodules, stage bronchogenic carcinoma, and evaluate inflammatory activity in...
154
¹³C NMR: ¹H–¹³C Decoupling01:04

¹³C NMR: ¹H–¹³C Decoupling

1.1K
The probability of having two carbon-13 atoms next to each other is negligible because of the low natural abundance of carbon-13. Consequently, peak splitting due to carbon-carbon spin-spin coupling is not observed in spectra. However, protons up to three sigma bonds away split the carbon signal according to the n+1 rule, resulting in complicated spectra.
A broadband decoupling technique is used to simplify these complex, sometimes overlapping, signals. Broadband decoupling relies on a...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Imaging the hallmarks of cancer.

Nature reviews. Cancer·2026
Same author

Imaging progenitor cell differentiation during central nervous system remyelination using an MRI gene reporter.

Brain : a journal of neurology·2026
Same author

Special Issue on "Machine Learning-Aided Medical Image Analysis".

Bioengineering (Basel, Switzerland)·2026
Same author

Integrating Foundation Model Features into Graph Neural Network and Fusing Predictions with Standard Fine-Tuned Models for Histology Image Classification.

Bioengineering (Basel, Switzerland)·2025
Same author

Early Detection of Cell Death Using Transmembrane Water Exchange Magnetic Resonance Imaging.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2025
Same author

Imaging progenitor cell differentiation during central nervous system remyelination using an MRI gene reporter.

bioRxiv : the preprint server for biology·2025

Related Experiment Video

Updated: Jul 23, 2025

Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy and Imaging
11:43

Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy and Imaging

Published on: December 30, 2016

10.5K

Hyperpolarized Carbon-13 MRI in Breast Cancer.

Ramona Woitek1,2,3, Kevin M Brindle3,4,5

  • 1Research Centre for Medical Image Analysis and AI, Danube Private University, 3500 Krems, Austria.

Diagnostics (Basel, Switzerland)
|July 14, 2023
PubMed
Summary

Hyperpolarized 13C-MR imaging (HP 13C-MRI) tracks tumor metabolism by visualizing pyruvate conversion. This advanced imaging technique shows promise for early cancer detection and treatment response assessment.

Keywords:
breast cancercarbon-13hyperpolarizationmagnetic resonance imagingmetabolism

More Related Videos

Tracking the Mammary Architectural Features and Detecting Breast Cancer with Magnetic Resonance Diffusion Tensor Imaging
15:48

Tracking the Mammary Architectural Features and Detecting Breast Cancer with Magnetic Resonance Diffusion Tensor Imaging

Published on: December 15, 2014

22.5K
Measuring the Spin-Lattice Relaxation Magnetic Field Dependence of Hyperpolarized [1-13C]pyruvate
11:57

Measuring the Spin-Lattice Relaxation Magnetic Field Dependence of Hyperpolarized [1-13C]pyruvate

Published on: September 13, 2019

6.6K

Related Experiment Videos

Last Updated: Jul 23, 2025

Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy and Imaging
11:43

Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy and Imaging

Published on: December 30, 2016

10.5K
Tracking the Mammary Architectural Features and Detecting Breast Cancer with Magnetic Resonance Diffusion Tensor Imaging
15:48

Tracking the Mammary Architectural Features and Detecting Breast Cancer with Magnetic Resonance Diffusion Tensor Imaging

Published on: December 15, 2014

22.5K
Measuring the Spin-Lattice Relaxation Magnetic Field Dependence of Hyperpolarized [1-13C]pyruvate
11:57

Measuring the Spin-Lattice Relaxation Magnetic Field Dependence of Hyperpolarized [1-13C]pyruvate

Published on: September 13, 2019

6.6K

Area of Science:

  • Oncology
  • Medical Imaging
  • Metabolic Engineering

Background:

  • Cancer is characterized by metabolic reprogramming, notably the Warburg effect (aerobic glycolysis).
  • Pyruvate, a key glucose metabolite, is central to tumor metabolism.
  • Hyperpolarized 13C-MR imaging (HP 13C-MRI) offers high sensitivity for tracking metabolic processes.

Purpose of the Study:

  • To evaluate the potential of HP 13C-MRI for clinical assessment of tumor metabolism.
  • To explore the application of HP 13C-MRI in breast cancer imaging for phenotyping and treatment monitoring.
  • To discuss the future clinical translation of hyperpolarized imaging agents.

Main Methods:

  • Utilizing hyperpolarized [1-13C]pyruvate for in vivo metabolic imaging.
  • Employing 13C-MR imaging to track the location and metabolism of the injected tracer.
  • Combining HP 13C-MRI with conventional 1H-MRI for anatomical and functional imaging.

Main Results:

  • HP 13C-MRI can detect and track the in vivo metabolism of hyperpolarized pyruvate with high sensitivity.
  • The technique allows for functional tumor phenotyping and early identification of treatment response.
  • Other hyperpolarized agents like [13C]urea and [1,4-13C2]fumarate show potential for imaging perfusion and cell death.

Conclusions:

  • HP 13C-MRI is a promising tool for evaluating tumor metabolism and guiding cancer treatment.
  • Integration with 1H-MRI enhances its utility in clinical breast imaging.
  • Reducing technical complexity and cost is crucial for wider clinical adoption.