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Related Concept Videos

Proteomics01:33

Proteomics

7.5K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
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Dynamic Changes in Proteome during Yak Oocyte Maturation Analyzed Using iTRAQ Technology.

Xin Ma1,2, Meng Wang1,2, Jinglei Wang1,2

  • 1College of Veterinary Medicine, Gansu Agricultural University, Lanzhou 730070, China.

Animals : an Open Access Journal From MDPI
|July 14, 2023
PubMed
Summary
This summary is machine-generated.

Yak oocyte maturation involves dynamic proteome changes, with distinct metabolic and genetic activities at different stages. Understanding these protein shifts aids in analyzing the molecular regulation of yak oocyte development.

Keywords:
differential proteomicsiTRAQoocytesyak

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Area of Science:

  • Reproductive Biology
  • Proteomics
  • Molecular Biology

Background:

  • Yak oocyte maturation is crucial for reproductive success.
  • Understanding the molecular mechanisms governing oocyte maturation is essential.

Purpose of the Study:

  • To investigate dynamic proteomic changes during in vitro maturation of yak oocytes.
  • To identify key proteins and pathways involved in yak oocyte development at different stages (GV, MI, MII).

Main Methods:

  • In vitro maturation of yak oocytes.
  • Differential proteomics sequencing using iTRAQ technology.
  • Bioinformatic analyses including Gene Ontology (GO), KOG, and KEGG pathway analysis.

Main Results:

  • Identified differential proteins associated with metabolic processes and molecular binding.
  • Observed increased energy metabolism from GV to MI stage, and genetic material preparation from MI to MII stage.
  • Enriched pathways include PPAR, Hippo signaling, ECM-receptor interaction (GV-MI) and PI3K-Akt, TGF-β, phagosome (MI-MII).

Conclusions:

  • Significant proteomic and functional shifts occur during yak oocyte maturation.
  • Specific pathways are dynamically regulated, influencing oocyte development.
  • This study provides insights into the molecular regulatory mechanisms of yak oocyte maturation.