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Updated: Jul 23, 2025

Optimization of the Ugi Reaction Using Parallel Synthesis and Automated Liquid Handling
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Bayesian Optimization-Assisted Screening to Identify Improved Reaction Conditions for Spiro-Dithiolane Synthesis

Masaru Kondo1,2, Hettiarachchige Dona Piyumi Wathsala3, Kazunori Ishikawa1

  • 1SANKEN, Osaka University, Ibaraki-shi 567-0047, Japan.

Molecules (Basel, Switzerland)
|July 14, 2023
PubMed

Keywords:
Bayesian optimization (BO)Gaussian process regression (GPR)Latin hypercube sampling (LHS)process chemistryrandom screeningscalable synthesisspiro-dithiolane

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