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Iodine(V)-Based Oxidants in Oxidation Reactions.

Samata E Shetgaonkar¹, Subhiksha Jothish², Toshifumi Dohi³

¹School of Chemical Sciences, Goa University, Taleigao Plateau 403206, Goa, India.

Molecules (Basel, Switzerland)

|July 14, 2023

Summary

Hypervalent iodine(V) reagents offer mild, environmentally friendly oxidation pathways in organic synthesis, mimicking transition metals. This review highlights their diverse applications in oxidation reactions over the last decade.

Keywords:

catalyst hypervalent iodine(V) reagents oxidant oxidation

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Area of Science:

Organic Chemistry
Green Chemistry
Oxidation Reactions

Background:

Hypervalent iodine reagents exhibit reactivity under mild conditions, similar to transition metals.
Their environmentally benign nature aligns with Green Chemistry principles.
Iodine(III) reagents act as electrophiles, while iodine(V) reagents are potent oxidants.

Purpose of the Study:

To review oxidation reactions facilitated by iodine(V) reagents.
To cover advancements in the past decade.
To emphasize the synthetic utility of hypervalent iodine(V) compounds.

Main Methods:

Literature review of oxidation reactions.
Focus on iodine(V) reagents like IBX and DMP.
Analysis of stoichiometric and catalytic applications.

Main Results:

Iodine(V) reagents are effective oxidants in various organic transformations.
Demonstrated utility in both stoichiometric and catalytic processes.
Highlighting the versatility and efficiency of these reagents.

Conclusions:

Hypervalent iodine(V) reagents are valuable tools in modern organic synthesis.
Their application promotes sustainable chemical practices.
Continued research promises further expansion of their synthetic scope.