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Correlation between erectile dysfunction and serum B12 levels: a 136-case cross-sectional analysis
Mevlüt Keleş1, Abdullah Çırakoğlu1, Erdal Benli1
1Education and Research Hospital, Department of Urology, Ordu University, Ordu, Turkey.
Andrology
|July 14, 2023
Summary
This study found no significant link between vitamin B12 (vit B12) levels and erectile dysfunction (ED) in men after excluding other causes. Further research is needed to fully understand the relationship between vit B12 and ED.
Area of Science:
- Urology
- Endocrinology
- Nutritional Science
Background:
- Erectile dysfunction (ED) is a common condition affecting sexual health, with multifactorial etiology.
- Understanding the role of specific nutrients, such as vitamin B12 (vit B12), in ED is crucial for comprehensive patient care.
Purpose of the Study:
- To investigate the correlation between serum vitamin B12 (vit B12) levels and erectile dysfunction (ED).
- To assess this relationship in a carefully selected group of male patients, excluding other known predisposing factors for ED.
Main Methods:
- A cohort of 136 male patients attending a urology clinic between 2015 and 2022 were included.
- Patients were categorized based on serum vit B12 levels (low ≤200 mg/dL vs. normal). Erectile function was assessed using the Sexual Health Inventory for Men-5 (SHIM-5).
- Exclusion criteria were stringent, removing patients with comorbid diseases, medication use, or surgical history that could influence ED.
Main Results:
- No statistically significant difference in SHIM-5 scores was observed between patients with low vit B12 levels and those with normal levels (p=0.575).
- Vitamin B12 deficiency was found in 23.5% of the study cohort.
- No significant association was noted between vit B12 levels and the presence of sexual desire disorder.
Conclusions:
- This study did not find a significant correlation between serum vitamin B12 levels and erectile dysfunction in men, contrary to some existing literature.
- Further well-designed prospective randomized controlled studies are warranted to elucidate the complex relationship between vitamin B12 and ED.
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