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CD34 Protein: Its expression and function in inflammation.

Carolina Rego Rodrigues1, Sahib Moga2, Baljit Singh1

  • 1Veterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, SK, S7N5B4, Canada.

Cell and Tissue Research
|July 14, 2023
PubMed
Summary
This summary is machine-generated.

CD34 is a cell marker used for hematopoietic stem cells (HSCs) and other cell types. This review explores CD34

Keywords:
CD34InflammationLPSLung injuryStem cells

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Area of Science:

  • Immunology
  • Cell Biology
  • Hematology

Background:

  • CD34 is a well-established marker for hematopoietic stem cells (HSCs), crucial for transplantation research.
  • Its expression extends beyond HSCs to muscle satellite cells and epidermal precursors.
  • Despite extensive use, the precise physiological role of CD34 in animals remains largely unknown.

Purpose of the Study:

  • To review the structure, evolutionary conservation, and proposed functions of CD34.
  • To examine the role of CD34 in the context of lung inflammation.
  • To synthesize current research and guide future investigations into CD34's biological significance.

Main Methods:

  • Literature review of existing studies on CD34.
  • Analysis of CD34 expression patterns across different species and cell types.
  • Synthesis of data related to CD34's function in physiological and pathological conditions, including lung inflammation.

Main Results:

  • CD34 is evolutionarily conserved across multiple species, suggesting a fundamental biological role.
  • Evidence points to CD34's involvement in processes beyond stem cell identification, including roles in inflammation.
  • Current research highlights CD34's multifaceted functions that warrant further in-depth study.

Conclusions:

  • CD34's established role as a cell marker is complemented by emerging evidence of its broader physiological functions.
  • Further research is needed to fully elucidate CD34's function, particularly its involvement in lung inflammation.
  • Understanding CD34's complete role will advance basic science and clinical applications in transplantation and beyond.