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Related Experiment Video

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Cell-Free DNA Integrity Analysis in Urine Samples
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Liquid Biopsy in Bladder Cancer.

Yan Cui1, Muyang Cao1

  • 1Department of Urology, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, People's Republic of China.

Methods in Molecular Biology (Clifton, N.J.)
|July 14, 2023
PubMed
Summary

Liquid biopsy using circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA) shows promise for bladder cancer detection. This review covers recent advances and challenges in using these biomarkers in body fluids.

Keywords:
Bladder cancerCirculating RNACirculating tumor DNACirculating tumor cellsExosomeUrinary tumor DNA

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Area of Science:

  • Oncology
  • Molecular Diagnostics
  • Urology

Background:

  • Liquid biopsy offers a minimally invasive approach for cancer detection and monitoring.
  • Key analytes include circulating tumor cells (CTCs), circulating tumor DNA (ctDNA), exosomes, and circulating RNA.
  • Bladder cancer diagnosis and management can benefit from advancements in liquid biopsy techniques.

Purpose of the Study:

  • To review recent findings and discuss challenges in liquid biopsy for bladder cancer.
  • To focus on the utility of CTCs, ctDNA, urinary tumor DNA, exosomes, and circulating RNA.

Main Methods:

  • Literature review of recent studies on liquid biopsy in bladder cancer.
  • Analysis of data concerning CTCs, ctDNA, urinary tumor DNA, exosomes, and circulating RNA.
  • Discussion of current issues and future directions in the field.

Main Results:

  • Liquid biopsy markers like CTCs and ctDNA show potential for bladder cancer detection and monitoring.
  • Exosomes and circulating RNA also represent promising avenues for bladder cancer diagnostics.
  • Several challenges remain, including standardization, sensitivity, and specificity of current methods.

Conclusions:

  • Liquid biopsy holds significant promise for transforming bladder cancer diagnostics and management.
  • Further research and technological advancements are needed to overcome current limitations.
  • Standardized protocols are crucial for the clinical translation of liquid biopsy in bladder cancer.