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Updated: Jul 23, 2025

Quantification of Protein Interaction Network Dynamics using Multiplexed Co-Immunoprecipitation
Published on: August 21, 2019
Centrality Analysis of Protein-Protein Interaction Networks Using R
1Independent Researcher, Jijamata Nagar, Hingoli, India. vijay.muley@comunidad.unam.mx.
Abstract:
Proteins are structural and functional components of cells. They interact with each other to drive specific cellular functions. The physical and functional protein interactions are an important feature of cellular organization and regulation. Protein interactions are represented as a network or a graph in which proteins are nodes, and interactions between them are edges. Perturbations in the network affecting essential or central proteins can have pathological consequences. Network or graph theory is a branch of mathematics that provides a conceptual framework to decipher topologically important proteins in the network. These concepts are known as centrality measures. This chapter introduces various centrality metrics and provides a stepwise protocol to quantify protein's strategic positions in the network using an R programming language.
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