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Updated: Jul 23, 2025

Two-dimensional Gel Electrophoresis Coupled with Mass Spectrometry Methods for an Analysis of Human Pituitary Adenoma Tissue Proteome
Published on: April 2, 2018
Non-coding RNAs and exosomal non-coding RNAs in pituitary adenoma
Neda Rahimian1, Amirhossein Sheida2, Mohammadreza Rajabi3
1Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences (IUMS), Tehran, Iran; Department of Internal Medicine, School of Medicine, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran.
Pituitary adenomas (PAs) are common brain tumors. Dysregulated non-coding RNAs (ncRNAs) show promise as biomarkers for early detection and potential therapeutic targets for pituitary adenomas.
Area of Science:
- Endocrinology and Oncology
- Molecular Biology and Genetics
Background:
- Pituitary adenoma (PA) is the third most common primary intracranial tumor.
- PAs are often diagnosed late due to asymptomatic nature, limiting surgical effectiveness.
- Early detection of PAs is crucial for improved patient outcomes and management.
Purpose of the Study:
- To review the expression patterns of dysregulated non-coding RNAs (ncRNAs) in pituitary adenomas.
- To explore the potential of ncRNAs as non-invasive biomarkers for PA diagnosis.
- To discuss ncRNAs as potential therapeutic targets for PA treatment.
Main Methods:
- Literature review summarizing ncRNA expression profiles in PAs.
- Analysis of microRNAs, long non-coding RNAs, and circular RNAs involved in PA.
- Discussion of molecular pathways implicated in PA pathogenesis by ncRNAs.
Main Results:
- Altered expression profiles of various ncRNAs (miRNAs, lncRNAs, circRNAs) are observed in PAs.
- These ncRNAs play roles in the molecular mechanisms underlying PA development and progression.
- Dysregulated ncRNAs represent a promising avenue for novel diagnostic and therapeutic strategies.
Conclusions:
- ncRNAs are significantly dysregulated in pituitary adenomas.
- ncRNA expression patterns offer potential for developing non-invasive biomarkers for early PA detection.
- ncRNAs may serve as innovative therapeutic targets for pituitary adenoma treatment.
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