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Small biopsies in the head and neck: Bone and soft tissue
Aarti E Sharma1, Darcy A Kerr2, Nicole A Cipriani3
1Hospital for Special Surgery, New York, NY, United States.
Seminars in Diagnostic Pathology
|July 15, 2023
Summary
Diagnosing head and neck bone and soft tissue lesions requires careful consideration of morphology, lineage, and grade. This approach aids in distinguishing between benign and malignant mesenchymal proliferations.
Area of Science:
- Oncology
- Pathology
- Head and Neck Surgery
Background:
- Head and neck bone and soft tissue lesions present a wide range of morphologies and clinicopathologic overlap.
- Accurate diagnosis is crucial for effective patient management and treatment planning.
Purpose of the Study:
- To outline a diagnostic strategy for mesenchymal proliferations in the head and neck.
- To emphasize the importance of integrating epidemiological, radiological, and locational data.
Main Methods:
- Stratification of diagnostic assessment by morphology (spindle, sarcomatoid, epithelioid, round cell).
- Classification based on cellular lineage (fibroblastic, nerve sheath, rhabdomyogenic).
- Tumor grading (benign, low- to high-grade malignant) guides further investigations.
Main Results:
- A systematic approach aids in navigating the complexities of mesenchymal tumor diagnosis.
- Morphologic, lineage, and grade-based stratification facilitates targeted immunohistochemical and molecular studies.
Conclusions:
- A structured diagnostic pathway is essential for accurate classification of head and neck mesenchymal lesions.
- This methodology supports precise diagnosis, enabling appropriate therapeutic interventions.
