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Expression of mTOR in normal and pathological conditions
A Marques-Ramos1, R Cervantes2,3,4
1H&TRC-Health & Technology Research Center, ESTeSL-Escola Superior de Tecnologia da Saúde, Instituto Politécnico de Lisboa, Lisbon, Portugal. ana.ramos@estesl.ipl.pt.
Molecular Cancer
|July 15, 2023
Summary
The mechanistic/mammalian target of rapamycin (mTOR) pathway regulates cellular balance. This study explores mTOR gene expression changes in diseases and its potential as a diagnostic and prognostic biomarker.
Area of Science:
- Molecular Biology
- Cellular Biology
- Biochemistry
Background:
- The mechanistic/mammalian target of rapamycin (mTOR) pathway is crucial for cellular homeostasis.
- mTOR integrates signals related to energy, nutrients, and hormones.
- Dysregulation of the mTOR pathway is linked to various human diseases.
Purpose of the Study:
- To review current data on mTOR gene expression regulation.
- To analyze mTOR expression changes in cancerous and non-cancerous diseases.
- To evaluate the potential of mTOR expression as a disease biomarker.
Main Methods:
- Literature review of existing data on mTOR gene expression.
- Systematization of knowledge on transcriptional, translational, and mRNA stability regulation of mTOR.
- Analysis of mTOR expression fluctuations in disease states.
Main Results:
- Insights into mTOR gene expression regulation are emerging.
- mTOR expression fluctuates in various diseases.
- Changes in mTOR expression are observed at transcriptional, translational, and mRNA stability levels.
Conclusions:
- Understanding mTOR gene expression regulation is vital.
- mTOR expression changes in disease warrant further investigation as biomarkers.
- This study provides a comprehensive view of mTOR expression in health and disease.
Keywords:
mTOR biomarkermTOR expressionmTOR expression cancermTOR expression diseasemTOR mRNA stabilitymTOR transcriptional regulationmTOR translation regulationMore Related Videos
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