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Related Experiment Video

Updated: Jul 23, 2025

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Gentamicin Eluting 3D-Printed Implants for Preventing Post-Surgical Infections in Bone Fractures.

Ishwor Poudel1, Manjusha Annaji1, Chu Zhang1

  • 1Department of Drug Discovery and Development, Harrison College of Pharmacy, Auburn University, Auburn, Alabama 36849, United States.

Molecular Pharmaceutics
|July 17, 2023
PubMed
Summary

This study developed 3D-printed orthopedic implants with a gentamicin coating to prevent infections. The implants showed sustained drug release, promoted cell growth, and effectively inhibited bacterial biofilm formation.

Keywords:
Additive ManufacturingGentamicinPolymerStainless Steel ImplantsSustained Release

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Area of Science:

  • Biomaterials Science
  • Orthopedic Engineering
  • Infectious Disease Research

Background:

  • Millions suffer from orthopedic injuries requiring implantable devices.
  • Postsurgical infections (PSIs) are a major cause of implant failure due to bacterial colonization.
  • Personalized orthopedic implants fabricated via additive manufacturing offer improved solutions.

Purpose of the Study:

  • To develop 3D-printed orthopedic implants using laser powder bed fusion (L-PBF).
  • To functionalize implants with a multilayered antimicrobial coating for PSI prevention.
  • To investigate the efficacy of gentamicin-loaded biodegradable polymer coatings.

Main Methods:

  • Fabrication of 3D-printed implants from 316L Stainless Steel using L-PBF.
  • Application of multilayered coatings using poly-d,l-lactide-co-glycolide (PLGA) loaded with gentamicin (GEN) via airbrush spray.
  • In vitro testing of drug release kinetics, cell adhesion, proliferation, viability, and antibacterial efficacy against Staphylococcus aureus and Staphylococcus epidermidis.

Main Results:

  • 3D-printed PLGA-GEN substrates sustained gentamicin release for approximately 6 weeks.
  • Surface modification enhanced cell adhesion and proliferation, with good cell viability.
  • Effective concentration-dependent antibacterial activity and significant biofilm inhibition were observed.

Conclusions:

  • 3D-printed implants with PLGA-GEN coatings show promise for preventing postsurgical infections.
  • The developed system offers versatile in vitro release rates, antimicrobial properties, and biocompatibility.
  • This technology has significant potential for future clinical applications in humans and animals, focusing on personalized antibiotic delivery.