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Updated: Jul 23, 2025

Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure
Published on: February 8, 2022
Positive Bubble Study But No Evidence of Interatrial Defect in a Patient with Recurrent Cryptogenic Stroke
Nika Samadzadeh Tabrizi1, Perry A Stout1, Joseph Cahill2
1Albany Medical College, New York, United States.
Pulmonary arteriovenous malformations (PAVMs) can cause serious complications and are often misdiagnosed as intracardiac shunts. Echocardiography can differentiate PAVMs from patent foramen ovale (PFO) or atrial septal defects (ASD).
Area of Science:
- Cardiology
- Radiology
- Pulmonology
Background:
- Pulmonary arteriovenous malformations (PAVMs) are often underdiagnosed due to rarity misconceptions.
- PAVMs can lead to severe complications like brain abscesses and cryptogenic emboli.
- Echocardiography findings of PAVMs can mimic intracardiac shunts (PFO/ASD), leading to misdiagnosis.
Purpose of the Study:
- To highlight the diagnostic challenges in PAVM identification.
- To emphasize the importance of recognizing unique echocardiographic features differentiating PAVMs from intracardiac shunts.
- To present a case of recurrent cryptogenic strokes misattributed to PFO, with PAVM diagnosed late.
Main Methods:
- Case report detailing a patient's diagnostic journey.
- Review of echocardiographic findings in PAVM versus intracardiac shunts.
- Analysis of diagnostic errors and delayed treatment.
Main Results:
- The patient experienced recurrent cryptogenic strokes.
- Initial diagnosis misattributed symptoms to a patent foramen ovale (PFO).
- Multiple PAVMs were correctly diagnosed only after two failed PFO closure attempts.
Conclusions:
- PAVMs represent an important alternative etiology for right-to-left shunting.
- Echocardiographers must be aware of specific imaging features to distinguish PAVMs from intracardiac defects.
- Timely and accurate diagnosis of PAVMs is crucial to prevent severe morbidity and mortality.
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