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Updated: Jul 23, 2025

Probing High-density Functional Protein Microarrays to Detect Protein-protein Interactions
Published on: August 2, 2015
Stranger Twins: A Tale of Resemblance and Contrast Between VAP Proteins
Mélody Subra1, Zoé Grimanelli1, Romain Gautier1
1Institut de Pharmacologie Moléculaire et Cellulaire, Inserm, CNRS, Université Côte d'Azur, Valbonne, France.
Abstract:
When considering the vesicle-associated membrane protein-associated protein (VAP) family, major receptors at the surface of the endoplasmic reticulum (ER), it appears that VAP-A and VAP-B paralogs largely overlap in structure and function, and that specific features to distinguish these two proteins hardly exist or are poorly documented. Here, we question the degree of redundancy between VAP-A and VAP-B: is one simply a backup plan, in case of loss of function of one of the two genes, or are there molecular and functional divergences that would explain their maintenance during evolution?
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