Pilot study on a new endoscopic platform for colorectal endoscopic submucosal dissection.

Area of Science:

• Gastroenterology
• Endoscopic Surgery
• Medical Devices

Background:

• Endoscopic submucosal dissection (ESD) is challenging due to operating field instability and loss of traction.
• Existing endoscopic resection techniques carry a higher risk of adverse events.
• A novel tissue retractor system (TRS) was developed to enhance intraluminal space stabilization and tissue traction during ESD.

Purpose of the Study:

• To evaluate the technical feasibility and clinical outcomes of a new endoscopic platform (TRS) in a pilot trial.
• To assess the efficacy and safety of TRS-assisted ESD for sigmoid and rectal lesions.

Main Methods:

• Prospective enrollment of patients undergoing ESD for sigmoid/rectal lesions.
• Evaluation of technical feasibility, en-bloc and R0 resection rates, procedure time, and adverse events.
• Comparison of TRS-assisted ESD with standard ESD techniques.

Main Results:

• TRS-assisted ESD was feasible in 8 out of 10 patients, primarily for rectal lesions.
• All rectal lesions were removed en-bloc with an 87.5% R0 resection rate.
• No intraprocedural or postprocedural adverse events were observed.

Conclusions:

• TRS-assisted ESD is a feasible and safe option for rectal lesions, demonstrating promising efficacy.
• The current TRS platform has technical limitations requiring further refinement for routine clinical application.