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Updated: Jul 23, 2025

Intravital Microscopy of the Inguinal Lymph Node
Published on: April 4, 2011
Granuloma inguinale diagnosed on the bedside
D Senkadhir Vendhan1, Biju Vasudevan1, Vinay Gera1
1Department of Dermatology, Armed Forces Medical College, Pune, Maharashtra, India.
Donovanosis, a rare genital ulcer disease caused by Klebsiella granulomatis, was diagnosed in a non-endemic area. Prompt bedside diagnosis using Donovan bodies in tissue smears enabled timely management.
Area of Science:
- Infectious Diseases
- Bacteriology
- Dermatology
Background:
- Donovanosis is a chronic bacterial infection caused by Klebsiella granulomatis.
- It presents as a painless, granulomatous genital ulcer, rare among sexually transmitted infections.
- The disease is typically confined to specific endemic regions globally.
Purpose of the Study:
- To report a rare case of donovanosis in a non-endemic area.
- To highlight the diagnostic challenges and successful management of an atypical presentation.
- To emphasize the importance of considering donovanosis in genital ulcer disease, even outside endemic zones.
Main Methods:
- Clinical presentation of a solitary genital ulcer.
- Initial diagnostic tests were inconclusive.
- Repeat tissue smear examination revealed Donovan bodies for bedside diagnosis.
Main Results:
- A patient in a non-endemic region presented with a solitary genital ulcer.
- Donovan bodies were identified on repeat tissue smear, confirming donovanosis.
- The diagnosis facilitated immediate and effective management.
Conclusions:
- Donovanosis can occur in non-endemic areas, challenging initial diagnoses.
- Bedside diagnosis via tissue smear for Donovan bodies is crucial for prompt management.
- Increased awareness is needed for this rare sexually transmitted infection in diverse geographical settings.
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