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Tissue-engineered edible bird's nests (TeeBN).

Yu Liu1, Yangyang Liu1, Jiayue Liu1

  • 1State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medicine & Department of Pharmaceutical Sciences, Faculty of Health Science, University of Macau, Taipa, Macau SAR.

International Journal of Bioprinting
|July 17, 2023
PubMed
Summary
This summary is machine-generated.

Tissue engineering created edible bird's nest (EBN) substitutes using 3D printing and cell culture. These novel TeeBNs offer comparable nutritional benefits to natural EBNs with reduced safety concerns.

Keywords:
3D printingCellular agricultureEdible bird’s nestsFood technologyTissue engineering

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Area of Science:

  • Biotechnology
  • Tissue Engineering
  • Food Science

Background:

  • Edible bird's nests (EBNs) are a delicacy in East Asia, but overharvesting raises ecological and food safety issues.
  • Traditional EBN harvesting faces sustainability and contamination challenges.

Purpose of the Study:

  • To develop a sustainable and safe alternative to natural EBNs using tissue engineering.
  • To create tissue-engineered edible bird's nests (TeeBNs) that mimic the nutritional and biological properties of natural EBNs.

Main Methods:

  • Fabrication of TeeBNs using a two-layer system: a feeding layer with epithelial cells in 3D-printed scaffolds and a receiving layer of food-grade polymers.
  • Encapsulation of epithelial cells to secrete bioactive compounds like sialic acid and EGF.
  • Characterization using in vitro assays and in vivo metabolomics studies in mice.

Main Results:

  • The feeding layer supported 3D cell growth and bioactive ingredient secretion.
  • The receiving layer contained essential nutrients and lacked common contaminants found in natural EBNs.
  • In vivo studies showed TeeBNs had a similar serum metabolite profile to natural EBNs, indicating comparable nutritional effects.

Conclusions:

  • A novel tissue-engineering approach successfully produced EBN substitutes (TeeBNs).
  • TeeBNs replicate the metabolic functions of natural EBNs while mitigating safety risks.
  • This innovation opens new possibilities for producing high-value food products through lab-based cell culture and 3D printing.