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Author Spotlight: Advancements in DNA Nanosensors – Addressing Sensitivity and Selectivity Challenges in Molecular Detection

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Stimuli-responsive nanozymes for biomedical applications.

Mengli Zhang¹, Weijun Tong¹

¹MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310058, China. tongwj@zju.edu.cn.

Biomaterials Science

|July 17, 2023

Summary

Stimuli-responsive nanozymes offer controllable activity for biomedical uses, overcoming the risks of always-on natural enzyme substitutes. This review explores their design, applications, and future potential in medicine.

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Area of Science:

Biomedical Engineering
Materials Science
Nanotechnology

Background:

Nanozymes are promising enzyme alternatives due to their stability and cost-effectiveness.
Uncontrolled activity of nanozymes poses risks in biomedical applications.
Stimuli-responsive nanozymes are developed to control nanozyme activity.

Purpose of the Study:

To review stimuli-responsive nanozymes and their biomedical applications.
To categorize stimuli-responsive nanozymes based on their activity control mechanisms.
To discuss the challenges and future directions in the field.

Main Methods:

Categorization of stimuli-responsive nanozymes into smart responsive types (on/off, one/another switchable) and carrier-released types.
Review of biomedical applications including cancer therapy, antibacterial therapy, biosensing, and anti-inflammatory therapy.
Analysis of current challenges and future prospects.

Main Results:

Two main types of stimuli-responsive nanozymes are identified: smart responsive and carrier-released.
These nanozymes demonstrate potential in various therapeutic and diagnostic applications.
The development of stimuli-responsive nanozymes offers enhanced safety and efficacy.

Conclusions:

Stimuli-responsive nanozymes are crucial for safe and effective biomedical applications.
Further research is needed to address challenges and unlock the full potential of these advanced nanomaterials.
This field holds significant promise for future medical innovations.