Related Experiment Video
Updated: Jul 23, 2025
05:08
A TNBS-Induced Rodent Model to Study the Pathogenic Role of Mechanical Stress in Crohn's Disease
Published on: March 1, 2022
4.0K
P001 Corticosteroid Induced Mood Changes in IBD.
1MCPHS University, Boston, Massachusetts, United States.
The American Journal of Gastroenterology
|July 18, 2023
Summary
Patients with inflammatory bowel disease (IBD) and depression/anxiety may benefit from antidepressants, but this increases the risk of steroid-induced mood changes. Healthcare providers must weigh these benefits and risks carefully.
Area of Science:
- Gastroenterology
- Psychiatry
- Pharmacology
Background:
- Depression and anxiety are common in inflammatory bowel disease (IBD).
- Corticosteroids, used for IBD flares, can cause neuropsychiatric side effects like hypomania and anxiety.
- Limited research exists on steroid effects on mood in IBD patients.
Purpose of the Study:
- To investigate the relationship between corticosteroid use and mood changes in patients with inflammatory bowel disease (IBD).
Main Methods:
- A systematic literature review was conducted.
- Searched databases included PubMed, CINHAL, PsychInfo, Medline, and Google Scholar.
- Inclusion and exclusion criteria were used to select relevant studies.
Main Results:
- Ten articles were reviewed, identifying themes of comorbid anxiety/depression in IBD, antidepressant effects, corticosteroid-induced mood changes, and at-risk populations.
- Antidepressant therapy can improve IBD symptoms.
- Patients on antidepressants face a higher risk of neuropsychiatric adverse effects from corticosteroids.
Conclusions:
- Antidepressants can improve IBD symptoms but increase the risk of corticosteroid-induced mood disturbances.
- Providers need to consider the dual risks and benefits of antidepressants and corticosteroids in IBD patients.
- Further research is needed to determine if antidepressant use reduces the need for corticosteroids in IBD patients.
Related Concept Videos
01:21Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
155
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
155
01:29Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
198
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
198
01:29Inflammatory Bowel Disease IV: Pharmacological Management
154
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
154
01:30Inflammatory Bowel Disease II: Crohn's Disease
298
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
298
01:24Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
175
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
175
01:29Drugs for Treatment of Ulcerative Colitis in IBD
175
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
175