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3D printing-mediated microporous starch hydrogels for wound hemostasis
Bo Zheng1, Zhipeng Qiu1, Jinchuan Xu1
1Ministry of Education Engineering Research Center of Starch & Protein Processing, Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety, School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China. felchen@scut.edu.cn.
This study presents a novel oxidized starch hydrogel loaded with calcium ions (CaOMS) for wound healing. CaOMS demonstrates rapid hemostasis and promotes effective wound healing, offering a promising alternative to traditional dressings.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Wound Healing Technologies
Background:
- Traditional wound dressings often lack biodegradability and cytocompatibility.
- Developing advanced materials for effective hemostasis and wound healing is crucial.
Purpose of the Study:
- To construct and evaluate an oxidized starch hydrogel loaded with calcium ions (CaOMS) using green hot-extrusion 3D printing (HE-3DP).
- To assess the hemostatic and wound healing capabilities of CaOMS both in vitro and in vivo.
Main Methods:
- Fabrication of CaOMS via green hot-extrusion 3D printing (HE-3DP).
- In vitro assessment of water absorption, blood cell, and platelet adhesion.
- In vivo evaluation of hemostasis, wound healing promotion, and growth factor expression (EGF, VEGF).
Main Results:
- CaOMS exhibited high water absorption (845.15-1194.20%) and promoted blood cell adhesion.
- In vivo studies showed rapid hemostasis (65 s) and effective wound healing.
- CaOMS enhanced epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF) expression.
Conclusions:
- CaOMS is a promising, low-cost biomaterial for rapid hemostasis and effective wound healing.
- The material's properties, including biodegradability and cytocompatibility, make it suitable for advanced wound care.
- 3D printing technology enables adaptable and efficient production of CaOMS for various wound shapes.
