Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A multimodal MRI-radiomics deep learning model for survival risk stratification after gamma knife radiosurgery in patients with brain metastases: A multicenter retrospective study.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2026
Same author

Evolution of the Neurometabolic Cascade of Traumatic Brain Injury.

Neurologic clinics·2026
Same author

Return-to-school protocols in pediatric concussion care.

Seminars in pediatric neurology·2026
Same author

Gray Matter Morphological Networks are Associated with Neurobiological Features, Cognitive Status and Clinical Recovery in Traumatic Brain Injury.

medRxiv : the preprint server for health sciences·2026
Same author

Liquid biopsy-based genomic risk score to predict neurologic death in non-small cell lung cancer patients.

Journal of neuro-oncology·2026
Same author

ComBat Harmonization With and Without Empirical Bayes Estimation for Resting-State Functional Connectivity in Pediatric Mild Traumatic Brain Injury: a CARE4Kids Study.

Research square·2026

Related Experiment Video

Updated: Jul 23, 2025

A Multi-Modal Approach to Assessing Recovery in Youth Athletes Following Concussion
10:31

A Multi-Modal Approach to Assessing Recovery in Youth Athletes Following Concussion

Published on: September 25, 2014

13.5K

CARE4Kids Study: Endophenotypes of Persistent Post-Concussive Symptoms in Adolescents: Study Rationale and Protocol.

Christopher C Giza1,2,3, Gerard Gioia4, Lawrence J Cook5

  • 1Department of Neurology, UCLA School of Medicine, University of California Los Angeles, Los Angeles, California, USA.

Journal of Neurotrauma
|July 18, 2023
PubMed
Summary

Researchers are developing objective biological measures to predict persistent post-concussive symptoms (PPCS) in adolescents after concussion. This aims to identify high-risk youth for targeted interventions and prevent long-term symptoms.

Keywords:
MRIadolescentautonomic nervous systembiomarkerbloodendophenotypepersistent post-concussion symptoms

More Related Videos

An Investigation of the Effects of Sports-related Concussion in Youth Using Functional Magnetic Resonance Imaging and the Head Impact Telemetry System
07:02

An Investigation of the Effects of Sports-related Concussion in Youth Using Functional Magnetic Resonance Imaging and the Head Impact Telemetry System

Published on: January 12, 2011

15.9K
A Neuroscientific Approach to the Examination of Concussions in Student-Athletes
11:32

A Neuroscientific Approach to the Examination of Concussions in Student-Athletes

Published on: December 8, 2014

12.8K

Related Experiment Videos

Last Updated: Jul 23, 2025

A Multi-Modal Approach to Assessing Recovery in Youth Athletes Following Concussion
10:31

A Multi-Modal Approach to Assessing Recovery in Youth Athletes Following Concussion

Published on: September 25, 2014

13.5K
An Investigation of the Effects of Sports-related Concussion in Youth Using Functional Magnetic Resonance Imaging and the Head Impact Telemetry System
07:02

An Investigation of the Effects of Sports-related Concussion in Youth Using Functional Magnetic Resonance Imaging and the Head Impact Telemetry System

Published on: January 12, 2011

15.9K
A Neuroscientific Approach to the Examination of Concussions in Student-Athletes
11:32

A Neuroscientific Approach to the Examination of Concussions in Student-Athletes

Published on: December 8, 2014

12.8K

Area of Science:

  • Neurology
  • Pediatrics
  • Biomarker Research

Background:

  • Concussion treatment in youth is evolving, with guidelines emerging to direct care.
  • While most concussions resolve within 14-28 days, approximately 20% of adolescents experience persistent post-concussive symptoms (PPCS).

Purpose of the Study:

  • To develop and clinically validate objective biological measures for predicting PPCS risk in adolescents.
  • To respond to the National Institute of Neurological Diseases and Stroke's call for predictive biomarkers.

Main Methods:

  • Recruitment of a Development cohort (11-17 year olds) with concussion.
  • Collection of autonomic, neurocognitive, biofluid, and imaging biomarkers.
  • Validation of promising measures in a separate cohort and development of a predictive algorithm.

Main Results:

  • The study is designed to generate a battery of predictive measures for PPCS risk.
  • The ultimate goal is to identify high-risk youth for intervention.

Conclusions:

  • This research aims to enable early identification of adolescents at high risk for PPCS.
  • Development of a predictive algorithm will facilitate targeted interventions to prevent persistent symptoms.