ORNIDAZOL-BASED APPLICATION SORBENT WITH NANO SILICA AND ITS ANTIMICROBIAL ACTIVITY.

Area of Science:

• Biomaterials Science
• Wound Healing Research
• Nanotechnology in Medicine

Background:

• Purulent wounds and diabetic foot syndrome pose significant clinical challenges.
• Effective management of postoperative wound infections is crucial for patient recovery.
• Novel drug delivery systems are needed to improve therapeutic outcomes.

Purpose of the Study:

• To evaluate the efficacy of a novel sorbent, Ornidasil, containing ornidazole and nanosilicon.
• To investigate Ornidasil's effectiveness in experimental purulent wounds and clinical cases of diabetic foot syndrome.
• To assess Ornidasil's role in preventing postoperative wound suppuration.

Main Methods:

• Experimental wound healing study in rats using Ornidasil.
• Clinical evaluation of Ornidasil for diabetic foot syndrome treatment.
• Assessment of Ornidasil's efficacy in preventing surgical site infections in patients with purulent peritonitis.

Main Results:

• Ornidazole release from the nanosilicon matrix was facilitated by hydrogen bonding, ensuring sustained local drug delivery.
• In experimental groups, wound healing was 1.6–1.9 times faster with Ornidasil compared to controls.
• Clinical application showed a significant reduction in postoperative wound suppuration (12.5% vs. 31.6% in comparison group).

Conclusions:

• Ornidasil demonstrates superior efficacy in accelerating wound healing for diabetic foot syndrome.
• The combination of Ornidasil with a polyurethane wound protector markedly decreases postoperative wound suppuration.
• This nanosilicon-based ornidazole sorbent presents a promising therapeutic option for challenging wound conditions.