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Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
Published on: October 30, 2013
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Adenocarcinoma involving the urinary bladder
Pule Wang1, Michael Joiner2, Stephen Dzul1
1School of Medicine, Wayne State University, Detroit, Michigan, USA.
BMJ Case Reports
|July 18, 2023
Summary
This case study details a patient with recurrent adenocarcinoma, initially diagnosed as prostate cancer, which was later identified as colorectal in origin. Successful re-treatment with chemoradiation and stereotactic radiation therapy led to a positive response and no evidence of disease.
Area of Science:
- Oncology
- Radiation Oncology
- Gastroenterology
Background:
- A 70-year-old male with a history of prostate adenocarcinoma treated with external beam radiation therapy (EBRT) and brachytherapy presented with urinary symptoms.
- Cystoscopy revealed a bladder neck tumor, which pathology identified as high-grade adenocarcinoma, suspected to be of colorectal origin.
- Initial investigations including colonoscopy, imaging, and genomic analysis supported a colorectal primary, despite a history of prostate cancer.
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The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
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