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Re-irradiation of a Classic Kaposi's Sarcoma Using Volumetric Modulated Arc Therapy
Zhe Chen1, Steven Daveluy2, Geoff Baran1
1Radiation Oncology, Wayne State University School of Medicine, Detroit, USA.
Re-irradiation therapy effectively treated recurrent classic Kaposi's sarcoma in a patient whose lesions progressed after initial radiation. This approach showed positive short-term outcomes for managing this rare cancer.
Area of Science:
- Oncology
- Dermatology
Background:
- Classic Kaposi's sarcoma (KS) can present with cutaneous nodules and lymphedema.
- Treatment resistance necessitates exploring alternative therapeutic strategies.
Observation:
- A patient with advanced classic Kaposi's sarcoma experienced lesion progression despite topical alitretinoin and initial radiation therapy.
- New lesions developed on the right foot and lower leg 1.5 years post-radiation.
Findings:
- Re-irradiation using volumetric modulated arc therapy (VMAT) to 3300 cGy in 11 fractions led to complete resolution of skin lesions.
- Short-term follow-up revealed mild residual edema and tenderness.
Implications:
- Re-irradiation with VMAT appears to be a viable and effective option for managing refractory or recurrent classic Kaposi's sarcoma.
- Further long-term studies are warranted to assess the durability of response and potential side effects.
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