Related Experiment Video
Updated: Jul 23, 2025

12:23
Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
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Immunotherapy-induced exclusively cutaneous sarcoid-like reaction
Anika Mazumder1, Sino Mehrmal2, Sofia Chaudhry3
1Saint Louis University School of Medicine, Saint Louis, Missouri, USA.
BMJ Case Reports
|July 18, 2023
Summary
Sarcoid-like reactions (SLRs) are rare inflammatory responses to immune checkpoint inhibitors (ICIs). This case highlights an exclusively skin-based SLR mimicking dermatomyositis, emphasizing the need for skin biopsy in diagnosing new eruptions.
Area of Science:
- Immunology
- Dermatology
- Oncology
Background:
- Sarcoid-like reactions (SLRs) are uncommon granulomatous inflammatory responses.
- Immune checkpoint inhibitors (ICIs) can trigger SLRs affecting various organs, notably lungs, lymph nodes, and skin.
- Cutaneous SLRs are rare, particularly when presenting without systemic involvement.
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