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Bladder carcinosarcoma treated by cystectomy and adjuvant chemotherapy with good outcomes: a case report
Fadila Kouhen1, Zineb Dahbi2, Mohammed Afif3
1Department of Radiotherapy, International University Hospital Sheikh Khalifa, Mohammed VI University of Health Sciences (UM6SS), Casablanca, Morocco. fadila10m@hotmail.com.
Background:
Primary carcinosarcoma of the bladder is a rare and highly aggressive tumor, representing less than 1% of all bladder neoplasms. There is no specific treatment guideline has for carcinosarcoma of the bladder, and majority of published patients was treated exclusively by surgery.
Case Presentation:
We report a case of 65-year-old Moroccan man, presented with macroscopic hematuria, pollakiuria and painful urination. Histological analysis showed a biphasic epithelial and mesenchymal proliferation, with invasion of lamina propria and muscularis, compatible with diagnosis of bladder carcinosarcoma. The patient was treated with cystectomy and adjuvant chemotherapy based on gemcitabin-cisplatin, 18 months after treatment, patient still free of recurrence.
Conclusion:
Carcinosarcoma of the urinary bladder is a rare and aggressive tumor regardless treatment. A multidisciplinary management based on radical cystectomy and combined adjuvant treatments can improve prognosis. In this work, we suggest to propose adjuvant chemotherapy whenever possible.
