Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pericarditis III: Medical Management01:17

Pericarditis III: Medical Management

15
The primary objectives of managing pericarditis are to determine the underlying cause, provide effective therapy for treatment and symptom relief, and promptly detect signs and symptoms of cardiac tamponade. The following outlines the essential aspects of medical management for pericarditis:ObjectivesDetermine the Cause: Identifying the underlying cause of pericarditis is crucial for targeted treatment. Causes include viral infections, autoimmune diseases, post-cardiac injury syndrome, and...
15

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cross-Sectional Survey of Unmet Needs in Children With NF1 and Cutaneous Neurofibromas: The Role of Pediatric Dermatology.

Pediatric dermatology·2026
Same author

International Age and Use Criteria for Transcatheter and Surgical Aortic Valve Replacement.

Reviews in cardiovascular medicine·2026
Same author

Targeting cellular senescence in dermatology: senolytic and senomorphic strategies.

GeroScience·2026
Same author

Fast-conducting mechanonociceptors uniquely engage reflexive and affective pain circuitry to drive protective responses.

Neuron·2026
Same author

Failure to rescue in cardiac surgery is not the same as preoperative mortality risk.

The Journal of thoracic and cardiovascular surgery·2026
Same author

Open-Geometry PET: Quantifying the Trade-off Between Time-of-Flight Resolution and Angular Coverage.

Physics in medicine and biology·2026

Related Experiment Video

Updated: Jul 23, 2025

Investigation of Beige Fat Biology and Metabolism Using the CRISPR SunTag-p65-HSF1 Activation System
09:52

Investigation of Beige Fat Biology and Metabolism Using the CRISPR SunTag-p65-HSF1 Activation System

Published on: January 6, 2023

2.3K

Injectable ice slurry for reducing pericardial adipose tissue.

Jeffrey Shuhaiber1, Sara Moradi Tuchayi1, Felicitas J Bijari2

  • 1Wellman Center for Photomedicine, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Lasers in Surgery and Medicine
|July 19, 2023
PubMed
Summary

Injectable ice slurry safely and effectively reduced pericardial adipose tissue (PAT) volume in a preclinical model. This novel cryolipolysis approach shows potential for treating cardiovascular diseases by targeting excess PAT.

Keywords:
coolingcryolipolysispericardial adipose tissuepericardial fatslurry

More Related Videos

Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus
07:24

Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus

Published on: January 23, 2018

10.4K
An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart
10:28

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart

Published on: June 7, 2015

17.4K

Related Experiment Videos

Last Updated: Jul 23, 2025

Investigation of Beige Fat Biology and Metabolism Using the CRISPR SunTag-p65-HSF1 Activation System
09:52

Investigation of Beige Fat Biology and Metabolism Using the CRISPR SunTag-p65-HSF1 Activation System

Published on: January 6, 2023

2.3K
Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus
07:24

Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus

Published on: January 23, 2018

10.4K
An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart
10:28

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart

Published on: June 7, 2015

17.4K

Area of Science:

  • Cardiology
  • Medical Devices
  • Adipose Tissue Research

Background:

  • Excess pericardial adipose tissue (PAT) is linked to increased cardiovascular disease risk.
  • Current PAT reduction methods (diet, exercise, medication, surgery) suffer from poor long-term patient compliance.
  • A novel injectable ice slurry technology offers selective subcutaneous adipose tissue reduction.

Purpose of the Study:

  • To evaluate the feasibility and safety of using an injectable ice slurry for selective reduction of pericardial adipose tissue (PAT) volume.
  • To assess the efficacy of slurry injection in a large animal model.

Main Methods:

  • Pericardial adipose tissue (PAT) in Yucatan swine was injected with either ice slurry or a control solution.
  • Chest computed tomography (CT) was used for PAT volume quantification at baseline and 2 months post-injection.
  • Histological analysis was performed on harvested PAT specimens.

Main Results:

  • Slurry treatment was well-tolerated, inducing selective cryolipolysis in PAT.
  • CT imaging revealed a significant reduction in PAT volume (median -29.66%) in the slurry-treated group compared to controls (-1.50%) at 8 weeks (p < 0.05).

Conclusions:

  • Injectable slurry is a feasible and safe method for selectively reducing PAT volume in a large animal model.
  • This cryolipolysis technique effectively reduces PAT, suggesting potential as a novel therapeutic strategy for cardiovascular diseases.