Warfarin-Associated Fetal Subdural Hematoma Causing Severe Neurodevelopmental Delay: A Case Report

Area of Science:

• Obstetrics and Gynecology
• Neonatal Neurology
• Pharmacology

Background:

• Fetal subdural hematoma (FSH) is a serious antenatal condition with high morbidity and mortality.
• Causes of FSH include maternal and fetal risk factors, necessitating tailored management.
• Warfarin, an anticoagulant, poses specific risks during pregnancy.

Purpose of the Study:

• To present a case of warfarin-associated fetal subdural hematoma.
• To highlight the long-term neurodevelopmental outcomes.
• To emphasize preventative strategies and counseling for pregnant women on warfarin.

Main Methods:

• Case report presentation.
• Review of clinical management and outcomes.
• Discussion of antenatal surveillance and monitoring.

Main Results:

• A case of live birth following warfarin-associated FSH.
• Severe neurodevelopmental delay observed by 10 years of age in the affected child.
• Identification of warfarin as a potential cause of fetal intracranial hemorrhage.

Conclusions:

• Counseling on fetal intracranial hemorrhage risk is vital for pregnant women using warfarin.
• Antenatal follow-up with fetal sonography and strict INR monitoring are essential preventative measures.
• Warfarin-associated FSH can result in significant long-term neurodevelopmental deficits.