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Isoindigo-Based Dual-Acceptor Conjugated Polymers Incorporated Conjugation Length and Intramolecular Charge Transfer
Yu Wang1,2, Hongsen Wang1,2, Jinni Deng1,3
1Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, 610041, China.
Macromolecular Rapid Communications
|July 19, 2023
Summary
Researchers developed novel conjugated polymers for enhanced photothermal tumor therapy. These materials show high efficiency in converting near-infrared light into heat for cancer treatment.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Engineering
Background:
- Photothermal tumor therapy (PTT) and photoacoustic imaging (PA) offer noninvasive cancer treatment options.
- Developing efficient photothermal agents with high photostability and strong near-infrared (NIR) absorption is crucial but challenging.
Purpose of the Study:
- To synthesize and characterize novel isoindigo-based dual-acceptor conjugated polymers (CPs) for PTT.
- To evaluate their optical, electrochemical, and NIR photothermal conversion properties.
Main Methods:
- Green and nontoxic direct arylation polymerization (DArP) method used for synthesis.
- Characterization of optical, electrochemical, and photothermal conversion properties.
- Formation of nanoparticles (NPs) for evaluation.
Main Results:
- Three isoindigo-based dual-acceptor CPs (P-IIG-TPD, P-IIG-DPP, P-IIG-EDOT-BT) were synthesized.
- Polymers exhibit enhanced photothermal conversion efficiency (PCE) due to molecular design.
- P-IIG-EDOT-BT and P-IIG-DPP NPs showed high PCEs of 62% and 78% with strong NIR absorption.
Conclusions:
- Dual-acceptor conjugated polymers show promise as NIR photothermal conversion materials.
- Molecular design strategies can improve PCE for tumor diagnosis and treatment.
- This work guides the development of advanced CPs for cancer therapy.
Keywords:
NIR photothermal conversiondirect arylation polymerizationdual-acceptor conjugated polymersMore Related Videos
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