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Oxygen-Embedded Fused-Ring Structure for NIR-Triggered Multimodal Phototherapy of Laryngeal Cancer
Hao Liu1,2, Bo Yu1, Shiwen Zhong1
1Department of Otorhinolaryngology, The Second Hospital of Dalian Medical University, Dalian116023, Liaoning, China.
ACS Applied Materials & Interfaces
|August 13, 2026
Summary
New organic semiconductor nanoparticles offer advanced multimodal phototherapy for laryngeal cancer. These nanoparticles efficiently generate heat and reactive oxygen species under near-infrared light, leading to significant tumor regression with minimal organ damage.
Area of Science:
- Materials Science
- Nanotechnology
- Oncology
Background:
- Laryngeal cancer necessitates precise, minimally invasive treatments to preserve function.
- Developing novel therapeutic platforms is crucial for effective cancer management.
Purpose of the Study:
- To develop multifunctional nanoparticles for near-infrared (NIR)-triggered multimodal phototherapy of laryngeal cancer.
- To investigate the therapeutic efficacy of oxygen-embedded fused-ring organic semiconductor (COi8FIC) nanoparticles.
Main Methods:
- Synthesized oxygen-embedded fused-ring organic semiconductor (COi8FIC) nanoparticles.
- Evaluated photothermal conversion efficiency and reactive oxygen species (ROS) generation.
- Assessed in vitro and in vivo therapeutic effects on laryngeal cancer models.
Main Results:
- COi8FIC nanoparticles demonstrated high photothermal conversion efficiency (62%) and synergistic ROS generation (2.5x monotherapy).
- In vivo studies showed significant tumor growth inhibition (93.3%) and tumor regression upon NIR irradiation.
- Minimal irreversible organ damage was observed in treated subjects.
Conclusions:
- COi8FIC nanoparticles represent a promising platform for multimodal phototherapy.
- This approach offers a precise and effective strategy for laryngeal cancer treatment.
- The developed nanoparticles show potential for clinical translation in cancer therapy.
Keywords:
laryngeal cancermultimodal phototherapynear-infrared absorptionorganic semiconductorphotothermal/photodynamic therapyMore Related Videos
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