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Solid-Phase Synthesis of Nannocystin Ax and Its Analogues
Daiki Miyakita1, Kohei Kawanishi1, Akira Katsuyama1,2,3
1Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan.
The Journal of Organic Chemistry
|July 19, 2023
Abstract:
Solid-phase total synthesis of nannocystin Ax (1) was disclosed. A coupling reaction between a peptide and a polyketide moiety was conducted on a solid support, and macrocyclization was achieved by Mitsunobu cyclization. The established synthetic route was efficient to prepare its analogues, which contain different types of peptide moieties.
