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Updated: Jul 23, 2025
08:18
Induction and Validation of Cellular Senescence in Primary Human Cells
Published on: June 20, 2018
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New Horizons in cellular senescence for clinicians.
Miles D Witham1,2, Antoneta Granic1,2, Satomi Miwa3
1AGE Research Group, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle, UK.
Age and Ageing
|July 19, 2023
Summary
Cellular senescence, a key aging mechanism, drives age-related diseases. Interventions targeting senescence show promise for improving healthspan, not just lifespan.
Area of Science:
- Gerontology
- Cell Biology
- Molecular Biology
Background:
- Cellular senescence is a fundamental aging mechanism, involving irreversible cell cycle arrest.
- Senescence can be triggered by various stressors, not solely telomere shortening, leading to altered cellular functions.
- The senescence-associated secretory phenotype (SASP) contributes to chronic inflammation and disease progression.
Purpose of the Study:
- To review the role of cellular senescence in aging and age-related diseases.
- To explore the potential of senotherapeutics (senolytics/senostatics) for counteracting aging and disease.
- To discuss the challenges and future directions for senotherapeutic interventions.
Main Methods:
- Review of existing literature on cellular senescence and aging.
- Analysis of data from animal models and human studies on senescent cells.
- Discussion of potential therapeutic strategies and their limitations.
Main Results:
- Senescent cells are present in humans and contribute to multiple age-related diseases.
- Interventions aimed at preventing or reversing senescence show therapeutic potential.
- Senotherapeutics may offer a strategy to address multiple age-related conditions simultaneously.
Conclusions:
- Cellular senescence is a significant driver of aging and associated pathologies.
- Targeting senescence presents a promising avenue for promoting healthy aging and treating age-related diseases.
- Clinical success of senotherapeutics hinges on improving healthspan and requires careful outcome measurement.
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