Jove
Visualize
Contact Us

Related Concept Videos

Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

198
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
198
Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

699
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
699
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

10
Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
10
Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

591
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
591
Overview of Lipid Metabolism01:24

Overview of Lipid Metabolism

1.8K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
1.8K
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

13
Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
13

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A practical approach to Cardiopulmonary Exercise Testing: from functional evaluation to adapted exercise prescription.

European journal of preventive cardiology·2026
Same author

Reference equations for peak oxygen uptake during cycle ergometry based on body composition estimates.

BMJ open sport & exercise medicine·2026
Same author

Should we use fat-free mass or body mass and percentage body fat as separate predictors to predict maximum oxygen uptake?

BMJ open sport & exercise medicine·2026
Same author

Increased Walking Speed Reduces Hospitalization Rates in Patients with Cardiovascular Disease During Exercise-Based Secondary Prevention.

Journal of clinical medicine·2025
Same author

Sitting-rising test scores predict natural and cardiovascular causes of deaths in middle-aged and older men and women.

European journal of preventive cardiology·2025
Same author

Improvements in walking speed reduce mortality in patients with cardiovascular disease during exercise-based secondary prevention: findings from the ITER registry.

European journal of preventive cardiology·2025
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 23, 2025

Assessing Whole-Body Lipid-Handling Capacity in Mice
07:57

Assessing Whole-Body Lipid-Handling Capacity in Mice

Published on: November 24, 2020

4.1K

Dyslipidemia paradox: Analysis from the veterans exercise testing study.

Baruch Vainshelboim1, Jonathan Myers2

  • 1Center for Tobacco Research, Division of Medical Oncology, Department of Internal Medicine, the Ohio State University, Columbus, OH, United States of America.

Plos One
|July 19, 2023
PubMed
Summary

Higher total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels were paradoxically linked to a lower risk of all-cause mortality in men. This suggests a need to re-evaluate current dyslipidemia guidelines for cardiovascular disease prevention.

More Related Videos

Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF
03:42

Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF

Published on: March 29, 2024

1.5K
Fiber Type and Subcellular-Specific Analysis of Lipid Droplet Content in Skeletal Muscle
11:50

Fiber Type and Subcellular-Specific Analysis of Lipid Droplet Content in Skeletal Muscle

Published on: June 8, 2022

4.2K

Related Experiment Videos

Last Updated: Jul 23, 2025

Assessing Whole-Body Lipid-Handling Capacity in Mice
07:57

Assessing Whole-Body Lipid-Handling Capacity in Mice

Published on: November 24, 2020

4.1K
Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF
03:42

Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF

Published on: March 29, 2024

1.5K
Fiber Type and Subcellular-Specific Analysis of Lipid Droplet Content in Skeletal Muscle
11:50

Fiber Type and Subcellular-Specific Analysis of Lipid Droplet Content in Skeletal Muscle

Published on: June 8, 2022

4.2K

Area of Science:

  • Cardiovascular Medicine
  • Epidemiology
  • Clinical Research

Background:

  • Dyslipidemia is a known cardiovascular disease (CVD) risk factor, but its impact on mortality requires further clarification.
  • Established dyslipidemia criteria, such as those from the National Cholesterol Education Program (NCEP) Adult Treatment Panel (ATP) III, are widely used.
  • The association between dyslipidemia and all-cause mortality, particularly in men, remains an area of active investigation.

Purpose of the Study:

  • To investigate the association between established dyslipidemia criteria and all-cause mortality in a cohort of men.
  • To determine if higher levels of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) impact mortality risk.
  • To explore the relationship between high-density lipoprotein cholesterol (HDL-C) and all-cause mortality.

Main Methods:

  • A prospective cohort study involving 1,479 men (mean age 59.7 years) was conducted from 1987 to 2012.
  • Baseline measurements included TC, LDL-C, and HDL-C levels.
  • Cox proportional hazard models were used to analyze all-cause mortality, adjusting for conventional health risk factors.

Main Results:

  • Higher TC levels (≥240 mg/dL) were associated with a 37% lower risk of mortality compared to TC <200 mg/dL (HR=0.63, p=0.048).
  • Higher LDL-C levels (≥190 mg/dL) were associated with a 32% lower risk of mortality compared to LDL-C <130 mg/dL (HR=0.68, p=0.044).
  • Increased TC and LDL-C were linked to longer mean survival times (p=0.001), while HDL-C showed no significant association with mortality.

Conclusions:

  • Higher TC and LDL-C levels demonstrated an independent, paradoxical association with reduced all-cause mortality and increased survival in men.
  • These findings challenge current dyslipidemia guidelines and suggest a need for re-evaluation.
  • Further systematic reviews and meta-analyses are recommended to inform evidence-based recommendations for CVD prevention.