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Updated: Jul 23, 2025

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An epigenetic modulator with promising therapeutic impacts against gastrointestinal cancers: A mechanistic review on

Amirhossein Davoodvandi1, Mahdi Rafiyan2, Zatollah Asemi2

  • 1Cancer Immunology Project (CIP), Universal Scientific Education and Research Network (USERN), Tehran, Iran; Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, I.R. Iran.

Pathology, Research and Practice
|July 19, 2023
PubMed

Insights

Long non-coding RNAs (lncRNAs) are key in gastrointestinal cancers. These molecules show promise as non-invasive biomarkers for early detection, prognosis, and guiding therapy in patients.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Gastrointestinal cancers are a leading cause of cancer death worldwide.
  • Drug resistance in cancer cells significantly contributes to high mortality rates.
  • Non-coding RNAs (ncRNAs) are increasingly recognized for their role in cancer development.

Purpose of the Study:

  • To review the role of long non-coding RNAs (lncRNAs) in gastrointestinal cancer progression.
  • To explore the potential of lncRNAs as therapeutic targets.
  • To highlight the utility of circulating ncRNAs as non-invasive biomarkers.

Main Methods:

  • Literature review focusing on lncRNAs in gastrointestinal cancers.
  • Analysis of ncRNA regulatory mechanisms (epigenetic, miRNA interactions).
  • Assessment of lncRNAs in blood for biomarker potential.

Main Results:

  • lncRNAs play critical roles in the initiation, development, and maintenance of gastrointestinal cancers.
  • lncRNAs regulate gene expression through various mechanisms, including epigenetic modifications and miRNA interactions.
  • Circulating lncRNAs are detectable in blood and show potential as non-invasive biomarkers.

Conclusions:

  • lncRNAs are crucial in gastrointestinal cancer biology and progression.
  • lncRNAs represent promising therapeutic targets for gastrointestinal cancers.
  • Circulating lncRNAs offer a novel avenue for non-invasive cancer diagnostics and prognostics.
Keywords:
Colorectal cancerGastrointestinal cancerInitiationMicroRNA-195Mir-195Non-coding RNAsProgression

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