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Updated: Sep 9, 2025

Identification of Circular RNAs using RNA Sequencing
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Identification of Circular RNAs using RNA Sequencing

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Circular RNAs and Cancers.

Mohammad Mahdi Heidari1,2,3, Mohammad Saeid Moeinfar2,3, Mahdi Rafiyan2,3

  • 1Department of Pediatric, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Advances in Experimental Medicine and Biology
|August 31, 2025
PubMed
Summary
This summary is machine-generated.

Circular RNAs (circRNAs) are novel RNA molecules with crucial roles in cell function. Their abnormal presence in tumors drives cancer growth, offering potential as clinical biomarkers and therapeutic targets.

Keywords:
CancerCircular RNAsNoncoding RNAs

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Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Circular RNAs (circRNAs) are endogenous RNA molecules formed by back-splicing of pre-mRNAs.
  • They possess unique covalently closed circular structures.
  • Emerging roles include microRNA sponging, protein scaffolding, and gene expression regulation.

Purpose of the Study:

  • To examine advancements in circRNA research in cancer.
  • To focus on their molecular mechanisms.
  • To explore their clinical significance.

Main Methods:

  • Review of current scientific literature on circRNAs in cancer.
  • Analysis of molecular mechanisms underlying circRNA function in tumorigenesis.
  • Evaluation of circRNAs as potential clinical biomarkers and therapeutic targets.

Main Results:

  • Abnormal circRNA expression is linked to tumor progression.
  • CircRNAs contribute to uncontrolled cell proliferation, invasion, and evasion of cell death.
  • Dysregulated circRNAs play significant roles in various cancers.

Conclusions:

  • CircRNAs are implicated in key cancer hallmarks.
  • Their unique properties suggest potential as diagnostic markers.
  • CircRNAs represent promising targets for novel cancer therapies.