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Related Concept Videos

Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

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Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
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Aneurysm I: Introduction01:30

Aneurysm I: Introduction

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An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
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Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

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Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
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Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

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Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
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Aneurysm III: Interprofessional Care01:26

Aneurysm III: Interprofessional Care

10
Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...
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Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

38
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
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An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
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Granulomatous annular diseases.

Tugba Kevser Uzuncakmak1, Murat Durdu2, Ayse Serap Karadag3

  • 1Department of Dermatology, Memorial Health Group, Sisli Hospital, Istanbul, Turkey.

Clinics in Dermatology
|July 19, 2023
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Summary

This review covers noninfectious granulomatous annular skin disorders, detailing their clinical presentation, diagnosis, and management. Understanding these conditions is crucial for effective dermatologic treatment.

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Area of Science:

  • Dermatology
  • Pathology

Background:

  • Granulomatous skin disorders are a diverse group of diseases characterized by granuloma formation in the skin and other organs.
  • Cutaneous lesions often present as erythematous papules and plaques, sometimes in an annular pattern.
  • The exact causes are often unknown, but granulomas can link to systemic diseases, infections, metabolic issues, foreign bodies, environmental factors, or cancers.

Approach:

  • This review synthesizes current knowledge on noninfectious granulomatous annular skin disorders.
  • It examines clinical, histopathologic, and dermatoscopic findings.
  • It also covers differential diagnoses and therapeutic strategies.

Key Points:

  • Noninfectious granulomatous annular lesions require careful evaluation.
  • Histopathology and dermatoscopy are vital for diagnosis.
  • Treatment is guided by the specific cause, lesion extent, and severity.

Conclusions:

  • Accurate diagnosis of granulomatous skin disorders is essential for appropriate management.
  • This review provides a comprehensive overview for clinicians.
  • Further research into etiopathogenesis may reveal novel therapeutic targets.