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Modulation of carcinogenesis with selected GRAS nutraceuticals via Keap1-Nrf2 signaling pathway

Bhagyalakshmi Nair1,2, Jayaprakash K Adithya1,3, Gopika Chandrababu1,2

  • 1Department of Pharmacognosy, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, Kochi, Kerala, India.

Phytotherapy Research : PTR
|July 19, 2023
PubMed

Insights

Nutraceuticals can modulate the Keap1-Nrf2 pathway, impacting cancer development. While some compounds show promise in preclinical studies, further research is needed to confirm their effectiveness in cancer chemoprevention.

Area of Science:

  • Cellular signaling pathways
  • Cancer biology
  • Nutritional science

Background:

  • The Keap1-Nrf2 signaling cascade plays a dual role in cancer, potentially preventing or promoting it.
  • Nutraceuticals, derived from food sources, are recognized for their health benefits and potential in cancer chemoprevention.
  • The Nrf2 pathway's complex role includes protecting normal cells but also potentially aiding tumor growth.

Purpose of the Study:

  • To systematically review the role of 12 nutraceuticals in modulating the Nrf2/Keap1 signaling pathway.
  • To assess the potential of these nutraceuticals as cancer chemoprevention agents.
  • To highlight the most studied nutraceuticals within this context.

Main Methods:

  • Systematic analysis of existing literature on nutraceuticals and the Nrf2/Keap1 pathway.
  • Identification of key nutraceuticals investigated for their modulatory effects.
  • Focus on nutraceuticals with Generally Recognized As Safe (GRAS) certification.

Main Results:

  • Twelve nutraceuticals, including curcumin, sulforaphane, and resveratrol, were analyzed for their impact on Nrf2/Keap1 signaling.
  • Sulforaphane emerged as the most extensively studied GRAS-certified compound in modulating this pathway.
  • Preclinical evidence suggests potential roles for these nutraceuticals, but clinical validation is limited.

Conclusions:

  • Nutraceuticals show potential in modulating the Keap1-Nrf2 pathway for cancer chemoprevention.
  • Sulforaphane is a prominent nutraceutical studied for its effects on Nrf2/Keap1 signaling.
  • High-quality clinical research is essential to validate the therapeutic potential of these compounds.
Keywords:
Keap1 (Kelch-like ECH-associated protein 1)Nrf2 (nuclear factor erythroid 2 [NF-E2] factor 2)canceroxidative stressphytochemicals

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