Related Experiment Video

Updated: Jul 23, 2025

A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness
12:21

A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness

Published on: September 28, 2022

2.5K

Fatal Severe Fever with Thrombocytopenia Syndrome Virus and Pasteurella multocida Coinfection

Yukiko Sako1, Tatsuya Fujihara2, Ryosuke Ishida2

  • 1Hiroshima Prefectural Hospital, Japan.

Internal Medicine (Tokyo, Japan)
|July 19, 2023
PubMed

Insights

This case report details a fatal outcome of severe fever with thrombocytopenia syndrome (SFTS) complicated by Pasteurella multocida bacteremia in a patient with alcoholic cirrhosis. The rare coinfection led to rapid deterioration and death despite aggressive medical intervention.

Area of Science:

  • Infectious Diseases
  • Virology
  • Bacteriology

Background:

  • Severe fever with thrombocytopenia syndrome (SFTS) is a tick-borne viral illness with significant mortality.
  • Bacteremia, particularly with opportunistic pathogens, can complicate viral infections, especially in immunocompromised individuals.
  • Alcoholic cirrhosis is a known risk factor for severe infections and poor outcomes.

Observation:

  • A 65-year-old male with alcoholic cirrhosis presented with anorexia and fatigue.
  • Initial laboratory findings included pancytopenia and hepatic/renal dysfunction.
  • The patient rapidly progressed to impaired consciousness, mucosal hemorrhage, and septic shock.

Findings:

  • Polymerase chain reaction confirmed SFTS virus in blood and throat swabs.
  • Blood cultures identified Pasteurella multocida bacteremia.
  • Coinfection with SFTS virus and P. multocida was diagnosed.

Implications:

  • This case highlights the potential for severe coinfections in patients with underlying liver disease.
  • The rapid progression underscores the aggressive nature of SFTS and bacteremia.
  • Understanding such coinfections is crucial for developing effective treatment strategies and improving patient outcomes.
Keywords:
Huaiyangshan banyangvirusPasteurella multocidabacteremiasevere fever with thrombocytopenia syndromesevere fever with thrombocytopenia syndrome viruszoonosis

More Related Videos

An Experimental Model to Study Tuberculosis-Malaria Coinfection upon Natural Transmission of Mycobacterium tuberculosis and Plasmodium berghei09:02

An Experimental Model to Study Tuberculosis-Malaria Coinfection upon Natural Transmission of Mycobacterium tuberculosis and Plasmodium berghei

Published on: February 17, 2014

19.9K
Visualization of Streptococcus pneumoniae within Cardiac Microlesions and Subsequent Cardiac Remodeling08:25

Visualization of Streptococcus pneumoniae within Cardiac Microlesions and Subsequent Cardiac Remodeling

Published on: April 7, 2015

9.1K

Related Concept Videos

Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
14
Endocarditis I: Introduction01:25

Endocarditis I: Introduction

Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...
13
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
17
Myocarditis I: Introduction01:21

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
10
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
12
Viral Recombination00:57

Viral Recombination

Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
23.5K