Diffuse nodular hyperplasia and fibrosis of the liver in lead-poisoned mandrills

Two sibling mandrills with clinical evidence of lead intoxication showed previously unreported hepatic alterations. The younger animal had high lead concentrations in blood, kidneys, and liver and characteristic intranuclear inclusions in renal tubules and hepatocytes. The liver showed diffuse nodular regenerative hyperplasia. The older mandrill had high lead concentrations in blood only and resolving intranuclear inclusions in liver and kidneys. The liver showed prominent portal fibrosis with evidence of resolving diffuse nodular hyperplasia. Occipital horn hydrocephalus was also present.