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Essential hormones as carcinogenic hazards.

R J Hickey, R C Clelland, E J Bowers

    Journal of Occupational Medicine. : Official Publication of the Industrial Medical Association
    |April 1, 1979
    PubMed
    Summary
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    The Occupational Safety and Health Administration (OSHA) needs to revise its proposed carcinogen list. The current list incorrectly includes essential biochemicals alongside true hazards, necessitating a clearer distinction based on dosage and exposure.

    Area of Science:

    • Environmental Health
    • Toxicology
    • Occupational Safety

    Background:

    • The Occupational Safety and Health Administration (OSHA) proposed regulations for environmental substances with potential occupational carcinogenic risks.
    • The proposed list included known carcinogens and naturally occurring biochemicals without clear differentiation.

    Purpose of the Study:

    • To highlight the need for a reappraisal of the OSHA proposed list of environmental substances.
    • To advocate for a revised document that distinguishes between true health hazards and endogenous biochemicals.

    Main Methods:

    • Analysis of the substances included in the OSHA proposed list.
    • Review of existing toxicological data and regulatory criteria for carcinogenicity.

    Main Results:

    Keywords:
    BiologyCancerContraceptive Agents, ProgestinDiseasesEndocrine SystemEstradiolEstriolEstrogensEstroneGovernment AgenciesHormonesNeoplasmsPhysiologyProgestational HormonesProgesterone

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    • The OSHA list fails to distinguish between potent carcinogens and essential endogenous substances (e.g., hormones, sugars).
    • Lack of clear criteria for classifying substances as occupational health hazards.

    Conclusions:

    • A critical reappraisal of the OSHA list is essential for accurate risk assessment.
    • Revised regulations must specify conditions, including dosage and routes of exposure, under which substances pose health hazards.