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Can affinity of hemoglobin to oxygen to be a prognostic marker in critically ill COVID-19 patients?
G H Alay1, D Tatlisuluoglu1, G Turan1
1Intensive Care Unit, Basaksehir Cam and Sakura City Hospital, Istanbul, Turkey.
Background:
This study's objective is to determine the slope of the hemoglobin oxygen dissociation curve in critically ill patients who have COVID-19 along with blood gas measurements and how mortality might be impacted by this circumstance.
Aim:
It has been reported that the hemoglobin oxygen dissociation curve is not different from healthy patients in COVID-19. However, there are insufficient data on the behavior of the curve in patients who require intensive care.
Patients And Methods:
This retrospective study was conducted between 01.03.2021 and 01.07.2021 with patients who were followed up due to COVID-19 in adult intensive care unit. P50 and lactate value obtained from in vitro calculated blood gas analysis. The survival status of the patients was recorded.
Results:
The mean P50 value at the admission of nonsurvivors was significantly higher than survivors. In correlation analysis, a significant positive correlation was seen between P50, mortality, and lactate level at admission. SpO2, PaO2/FiO2 ratio, and length of stay in intensive care unit were significantly negatively correlated with P50 levels.
Conclusion:
A right shift in the hemoglobin oxygen dissociation curve is associated with mortality. Lactate levels were also associated with a right shift. Prospective experimental studies are needed to provide a better understanding of this process.
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