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Lymphomas affecting the submandibular glands.
G-R Araújo1, A-L Morais-Perdigão, C-V Lopez-de-Cáceres
1Department of Oral Surgery and Pathology, School of Dentistry Universidade Federal de Minas Gerais Av. Antônio Carlos, 6627. Belo Horizonte, Brazil felipepfonseca@hotmail.com.
Medicina Oral, Patologia Oral Y Cirugia Bucal
|July 20, 2023
Summary
Lymphomas of the submandibular gland are rare. Low-grade B cell lymphomas, such as MALT lymphoma, are most common, but aggressive subtypes like diffuse large B cell lymphoma can also occur.
Area of Science:
- Pathology
- Oncology
- Head and Neck Surgery
Background:
- Lymphomas involving submandibular glands are exceptionally rare.
- Limited literature exists on their clinical and microscopic characteristics.
Purpose of the Study:
- To detail the clinical and microscopic features of lymphomas in the submandibular glands.
- To contribute original data to the understanding of these uncommon neoplasms.
Main Methods:
- Retrospective review of 16 lymphoma cases from two institutions.
- Diagnosis confirmation using hematoxylin and eosin and immunohistochemical staining.
- Adherence to the 4th edition World Health Organization classification.
- Collection of clinical data from patient medical charts.
Main Results:
- 16 cases identified, with a female predominance (10:6) and a mean age of 57.8 years.
- Most tumors presented as asymptomatic swellings.
- The most frequent subtype was MALT lymphoma, followed by diffuse large B cell lymphoma (DLBCL) and follicular lymphoma.
- Three patient deaths occurred, including cases of plasmablastic lymphoma, DLBCL, and MALT lymphoma.
Conclusions:
- Low-grade B cell lymphomas are the predominant type in the submandibular gland.
- Aggressive subtypes, including DLBCL, are rarely encountered in this location.
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