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Lymphomas affecting the submandibular glands.

G-R Araújo¹, A-L Morais-Perdigão, C-V Lopez-de-Cáceres

¹Department of Oral Surgery and Pathology, School of Dentistry Universidade Federal de Minas Gerais Av. Antônio Carlos, 6627. Belo Horizonte, Brazil felipepfonseca@hotmail.com.

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|July 20, 2023

Summary

This summary is machine-generated.

Lymphomas of the submandibular gland are rare. Low-grade B cell lymphomas, such as MALT lymphoma, are most common, but aggressive subtypes like diffuse large B cell lymphoma can also occur.

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Area of Science:

Pathology
Oncology
Head and Neck Surgery

Background:

Lymphomas involving submandibular glands are exceptionally rare.
Limited literature exists on their clinical and microscopic characteristics.

Purpose of the Study:

To detail the clinical and microscopic features of lymphomas in the submandibular glands.
To contribute original data to the understanding of these uncommon neoplasms.

Main Methods:

Retrospective review of 16 lymphoma cases from two institutions.
Diagnosis confirmation using hematoxylin and eosin and immunohistochemical staining.
Adherence to the 4th edition World Health Organization classification.
Collection of clinical data from patient medical charts.

Main Results:

16 cases identified, with a female predominance (10:6) and a mean age of 57.8 years.
Most tumors presented as asymptomatic swellings.
The most frequent subtype was MALT lymphoma, followed by diffuse large B cell lymphoma (DLBCL) and follicular lymphoma.
Three patient deaths occurred, including cases of plasmablastic lymphoma, DLBCL, and MALT lymphoma.

Conclusions:

Low-grade B cell lymphomas are the predominant type in the submandibular gland.
Aggressive subtypes, including DLBCL, are rarely encountered in this location.