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[Role of Tranexamic Acid in Plastic Surgery: a Systematic Review]
Raya Isaev1, Elena Frey1, Melodi Motamedi1
1Klinik für Plastische und Ästhetische Chirurgie, Handchirurgie, Sana Klinikum Hameln-Pyrmont, Hameln, Germany.
Handchirurgie, Mikrochirurgie, Plastische Chirurgie : Organ Der Deutschsprachigen Arbeitsgemeinschaft Fur Handchirurgie : Organ Der Deutschsprachigen Arbeitsgemeinschaft Fur Mikrochirurgie Der Peripheren Nerven Und Gefasse : Organ Der V
|July 20, 2023
Summary
Tranexamic acid effectively reduces bleeding in plastic surgery, offering advantages over disadvantages for perioperative use. Further research is needed to establish its role and optimize its application in this field.
Area of Science:
- Plastic Surgery
- Pharmacology
- Surgical Hemostasis
Background:
- Perioperative bleeding is a significant concern in surgery, potentially leading to complications like anemia and the need for blood transfusions.
- Tranexamic acid, an antifibrinolytic agent, is recognized for managing bleeding in various surgical specialties.
- Its application in plastic surgery is gaining traction, supported by emerging individual studies.
Approach:
- A systematic literature review was conducted using MEDLINE, focusing on studies published between 2010 and 2023.
- Keywords included various applications of tranexamic acid in plastic surgery (intravenous, topical, subcutaneous).
- Included studies were randomized controlled trials and non-randomized prospective/retrospective cohort studies, excluding case reports and reviews.
Key Points:
- The literature search identified 135 papers, with 15 studies meeting the inclusion criteria for this review.
- Recommendations for intravenous, topical, and subcutaneous tranexamic acid use in plastic surgery were developed, including indications, contraindications, and dosages.
- The review found more advantages than disadvantages for the perioperative use of tranexamic acid in plastic surgery.
Conclusions:
- While evidence is still developing, tranexamic acid shows promise in reducing perioperative bleeding in plastic surgery, potentially enhancing surgical precision and enabling faster drain removal.
- Further randomized controlled trials are essential to fully establish the benefits and risks of tranexamic acid in plastic surgery.
- Optimizing the use of tranexamic acid can lead to improved patient outcomes and surgical efficiency.
