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Related Experiment Video

Updated: Jul 22, 2025

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Published on: November 8, 2012

Molecular-enriched functional connectivity in the human brain using multiband multi-echo simultaneous ASL/BOLD fMRI.

Ottavia Dipasquale¹, Alexander Cohen², Daniel Martins³

¹Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, De Crespigny Park, London, SE5 8AF, UK. ottavia.dipasquale@kcl.ac.uk.

Scientific Reports

|July 20, 2023

Summary

This summary is machine-generated.

Receptor-enriched analysis of functional connectivity by targets (REACT) successfully extended to ASL imaging, matching BOLD fMRI in revealing molecular pathways. ASL and BOLD fMRI offer complementary insights into brain function.

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Area of Science:

Neuroimaging
Molecular Neuroscience
Functional Neuroanatomy

Background:

Receptor-enriched analysis of functional connectivity by targets (REACT) integrates molecular data with functional magnetic resonance imaging (fMRI).
Previous REACT applications were limited to Blood-Oxygen-Level-Dependent (BOLD) fMRI.
Arterial Spin Labeling (ASL) fMRI offers a more direct measure of neuronal activity and is suitable for pharmacological studies.

Purpose of the Study:

To extend the REACT strategy to ASL fMRI.
To compare ASL-derived and BOLD-derived molecular-enriched functional connectivity (FC) maps.
To evaluate the spatial similarity and test-retest reproducibility of ASL and BOLD FC.

Main Methods:

Simultaneous ASL/BOLD resting-state fMRI data were acquired from 29 healthy subjects.
REACT was applied to estimate ASL and BOLD FC maps for six molecular systems.
Spatial similarity and test-retest reproducibility of ASL and BOLD FC maps were compared.

Main Results:

Robust spatial patterns of molecular-enriched FC were observed for both ASL and BOLD modalities.
Moderate spatial similarity was found between ASL and BOLD FC maps.
Test-retest reproducibility was comparable between ASL and BOLD FC for most molecular networks.

Conclusions:

ASL fMRI is as informative as BOLD fMRI for detecting functional circuits linked to specific molecular pathways.
ASL and BOLD fMRI may provide complementary information regarding molecular-enriched functional circuits.
The extension of REACT to ASL imaging broadens its applicability in neuroscience research.